The Innovative Medicines Initiative (IMI) project ‘Prioritisation and risk evaluation of medicines in the environment’ (PREMIER) has launched its database on environmental risk assessment of pharmaceuticals. The PREMIER database is an open platform to support science-based decisions during the assessment of potential risks of pharmaceuticals in the aquatic environment. ECT is involved in PREMIER as […]
Toxicokinetic-toxicodynamic (TKTD) modeling can integrate all available data from individual‐level bioassays into a single framework and enable refined risk assessments by extrapolating from laboratory results to time‐variable exposure scenarios. Dynamic energy budget (DEB) models coupled with TKTD modules (DEB-TKTD) are an approach to assess and predict sublethal effects of chemicals on individual organisms. However, thorough […]
The fish short-term reproduction test is an in vivo screening assay that provides information about possible endocrine-mediated effects on adult fish. Within the OECD Conceptual framework for the testing and assessment of endocrine disrupting chemicals, it is a level 3 assay. We perform this test according to OECD test guideline 229 (Fish short-term reproduction assay, […]
Fish early-life stage tests are required for environmental risk assessments of industrial chemicals, plant protection products, biocides, and human and veterinary pharmaceuticals to evaluate chronic effects on the sensitive early life stages of fish. We perform these tests according to OECD test guideline 210 (Fish, early-life stage toxicity test, revised in 2013) in compliance with […]
The environmental risk of pesticides for nontarget soil macroorganisms has mainly been assessed using the compost earthworm Eisenia fetida. However, E. fetida does not occur in agroecosystems and it is generally less sensitive than other earthworm species. Thus, the extrapolation of its response to pesticides to other earthworm species may lead to uncertainties in the […]
Low-risk pesticides including biopesticides consisting of plant extracts, semiochemicals such as pheromones and allelochemicals, and microbial pesticides are gaining ground in the global market, where they have started to substitute synthetic pesticides. In addition, phages, protists, microbial consortia and double-stranded (ds)-RNA pesticides are emerging low-risk solutions that are expected to reach the market in coming […]
Lead by Anja Coors, a team of partners in the IMI-funded project ‘Prioritisation and risk evaluation of medicines in the environment’ (PREMIER) developed and recently published a decision tree that shall help to minimize animal testing within PREMIER and beyond. The risk-driven decision tree uses a combination of experimental testing with non-vertebrates and a fish-specific […]
PRORISK is a European Training Network funded by the European Union’s Horizon 2020 research and innovation programme. It creates a platform for training early-stage researchers in the field of advanced environmental risk assessment. Environmental risk assessment procedures are nowadays changing, incorporating for instance mechanistic, ecological, and socio-economic information. Consequently, risk assessments are becoming more comprehensive. […]
Sunscreens containing UV filter substances, such as octocrylene (OCR) and butyl-methoxydibenzoylmethane (BMDBM), have been increasingly used to protect human skin against UV radiation. Both substances have been detected in monitoring studies in the freshwater and marine environment, and there has been concern about potential effects on aquatic organisms. In the present work, the environmental fate […]
As acknowledged by the European Food Safety Authority (EFSA) soil microorganisms play a key role in ecosystem functioning and there is a lack of appropriate methods to assess impacts on them. ARISTO, the European Industry-Academia Network for Revising and Advancing the Assessment of the Soil Microbial Toxicity of Pesticides, started in 2021 and addresses this […]
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K. Duis
K. Duis, M. Weil
K. Duis, M. Weil
D. Leib
T. Junker