Residues of veterinary pharmaceuticals enter the environment via application of manure onto agricultural land, where particularly antibiotics can cause phytotoxicity. Terrestrial plant tests according to OECD test guideline 208 are part of the environmental risk assessment of veterinary pharmaceuticals. However, this standard approach might not be appropriate for veterinary medicinal products forming non-extractable residues or transformation products in manure and manure-amended soil. To assess such products, a new test design including a more realistic exposure scenario via manure application is needed.