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New publication: Minimizing experimental testing on fish for legacy pharmaceuticals

Lead by Anja Coors, a team of partners in the IMI-funded project ‘Prioritisation and risk evaluation of medicines in the environment’ (PREMIER) developed and recently published a decision tree that shall help to minimize animal testing within PREMIER and beyond. The risk-driven decision tree uses a combination of experimental testing with non-vertebrates and a fish-specific […]

New publication: Uptake and effects of the beta‐adrenergic agonist salbutamol in fish: supporting evidence for the fish plasma model

The fish plasma model predicts the fish blood plasma concentration of a pharmaceutical from the water concentration to which the fish is exposed and compares it to the human therapeutic plasma concentration with the postulate that no adverse toxic effects occur below this concentration. The present study provides several lines of evidence supporting the fish […]