The Innovative Medicines Initiative (IMI) project PREMIER aims to develop a centralised, user-friendly digital assessment system accessible for all relevant stakeholders. PREMIER will also explore options to incorporate environment considerations earlier in the drug development process to inform drug design and to reduce the need of animal testing. ECT is involved in this project as […]
The Innovative Medicines Initiative (IMI) project ‘Prioritisation and risk evaluation of medicines in the environment’ (PREMIER) aims to develop a centralised, user-friendly and transparent digital assessment system accessible for all relevant stakeholders such as regulatory agencies, pharmaceutical industry, water managers and environmental non-governmental organisations. Furthermore, PREMIER will explore the options to incorporate environment considerations earlier […]
Because of their usually high molecular weight, polymers are generally considered as being of low environmental concern and are, therefore, exempted from registration and evaluation within REACH. This exemption is currently being reviewed by the European Commission. Against this background, data on the environmental fate and effects of selected water-soluble synthetic organic polymers used in […]
Protecting the structure and functioning of soil ecosystems is one of the central aims of current regulations of chemicals. This is, for instance, shown by the emphasis on the protection of key drivers and ecosystem services proposed by EFSA in the protection goal options for soil organisms. Such targets require insight into soil biodiversity, its […]
Despite the increasing use of pesticides in tropical countries, research and legislative efforts have focused on their temperate counterparts. In the present publication, the literature on environmental risk assessment of pesticides in tropical terrestrial ecosystems is reviewed. Potential differences in pesticide risks between temperate and tropical regions are evaluated, and research needs for tropical regions […]
For the treatment of groundwater contaminated with chlorinated hydrocarbons, nano-scaled zero-valent iron (nano Fe0) represents an efficient alternative to other treatments as e.g. pump & treat. Upon selection of a suitable treatment method for a given groundwater a risk-cost-benefit analysis is performed. This analysis does only rarely consider the potential risk of the remediation method […]
The persistence assessment under REACH relies on compartment‐specific degradation half‐lives derived from laboratory simulation studies with surface water, aquatic sediment or soil. Although these data are given priority, they are not available for most of the compounds. Therefore, according to the integrated assessment and testing strategy for persistence assessment, results from ready biodegradability tests are […]
The project objective was to identify and quantify uncertainties that occur in the environmental risk assessment (ERA) of pesticides, specifically for the soil compartment. The project was based on the assessment that the general approach of employing surrogate species and experimental setups to assess the effects of pesticides has certain shortcomings that affect the outcome […]
According to EU Directive 2001/18/EC, genetically modified organisms (GMO) must be assessed for potential risks to human health, animal and plant life, nature, and the environment prior to experimental release or market authorization. The concepts and methods used for this purpose must correspond to the state of the science and technology and consider the specific issues and characteristics of the testing of GMO […]
The interaction of pollutants and pathogens may result in altered (often enhanced) effects of the chemical, the biotic stressor or both. While standardised detection methods for immunotoxic effects of chemicals exist with regard to human health, such test systems are lacking for invertebrate species and no guidance is available on how immunotoxic effects of a […]
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Premier
K. Duis
K. Duis
J. Römbke
M. Weil
T. Junker
D. Leib
K. Duis
L. Schlüter-Vorberg