The project explored the suitability of the fish embryo toxicity test with the zebrafish, Danio rerio, (DarT) as a tool to screen for additive and non-additive effects among biocidal substances. Five biocidal products from the product type 8 (curative and preventive wood preservatives) and their individual active substances were tested in the DarT. Overall, the results provided clear evidence that the DarT can be used to verify if the toxicity of formulated biocidal products can reliably be predicted by the concept of concentration addition. This may open the possibility to replace vertebrate (adult or juvenile fish) testing by mixture toxicity predictions in justified cases.
ECT Oekotoxikologie GmbH is a privately owned enterprise that was founded in 1993.
In compliance with Good Laboratory Practice (GLP), we perform standardised ecotoxicological tests in the laboratory as well as at semi-field and field level.
Find us at
ECT Oekotoxikologie GmbH
Böttgerstraße 2 – 14
65439 Flörsheim am Main
Phone: +49 6145 9564-0
Fax: +49 6145 9564-99