Tag Archive for: GLP

Determination of developmental toxicity to dipterian dung flies

The aim of the project was to standardise a test guideline with two dung fly species to be used for the environmental risk assessment of veterinary pharmaceuticals, in particular endo- and ectoparasiticides excreted in dung. The test is designed to evaluate developmental toxicity of a test substance to the dung dwelling life stages of dung-dependent […]

Supply of dung beetles for the performance of a ring test as a precondition for the implementation of an OECD Guidance Document

The objective of this project sponsored by the German Federal Environment Agency was the improvement of existing laboratory tests with dung beetles and dung flies. It was aimed at identifiying a second dung beetle species for standardised laboratory tests that should belong to the ecological group of ‘tunnelers’.  However, it was not possible to establish […]

Development of a standardised laboratory test with dung beetles for the assessment of the ecotoxicity of veterinary pharmaceuticals

According to European law, the environmental risk assessment of veterinary pharmaceuticals for dung beetles is required for parasiticides for the treatment of pasture animals. Starting with recommendations from the SETAC advisory group DOTTS (Dung Organism Toxicity Test Standardisation), a test system using the widespread temperate dung beetle species Aphodius constans was developed. Together with the […]

Organisation and performance of an international ringtest for the validation of the enchytraeid reproduction test

An enchytraeid reproduction test ring test was performed in line with OECD requirements. Twenty-nine institutions (mainly universities and contract research laboratories) from 15 countries from Europe and North America participated in this ring test. The co-ordinating laboratory centrally distributed the test chemicals, guidance papers and test organisms to all participants. In addition, several training courses […]