Manure is widely used as a fertilizer and applied to agricultural land. It may contain highly active chemicals like veterinary medicinal products or biocides, which enter the environment by this pathway. This is recognized by several regulatory frameworks, however, a detailed method for examining the transformation of chemicals in manure was lacking. The present publication […]
On 30 June 2022, the OECD published test guideline No. 320: ‘Determining anaerobic transformation of chemicals in liquid manure’. This guideline describes a standardised method to investigate transformation of chemical substances in pig and cattle liquid manure under anaerobic conditions. The experiments are performed to determine the rate of transformation of the test substance, the […]
Products used for plant protection or as biocides often contain more than one active substance together with numerous formulation additives. The environmental risk assessment for such commercial mixtures applies as default the concept of concentration addition. There is remaining regulatory concern, however, that underestimation of risks can occur if components in the mixture interact synergistically, […]
The aquatic environment is continually exposed to a complex mixture of chemicals, with effluents of wastewater treatment plants (WWTPs) as one key source. The aim of the present study was to investigate whether environmental risk assessments addressing individual substances are sufficiently protective for such mixtures. Based on a literature review of chemicals reported to occur […]
The SETAC Pellston Workshop ‘Simplifying environmental mixtures – an aquatic exposure-based approach via exposure scenarios’ addressed the need to improve mixture assessments by considering different exposure scenarios related to land use. Recently, a series of papers from this workshop was published in Environmental Toxicology and Chemistry, including the work ‘Use of prospective and retrospective risk assessment methods that simplify chemical mixtures associated with treated domestic wastewater discharges’, to which Anja Coors contributed.
The recently published work ‘Environmental risk assessment of biocidal products: identification of relevant components and reliability of a component-based mixture assessment’ contributes to the currently ongoing debate on how to perform a mixture assessment in the environmental risk assessment within the authorisation process of biocidal products. Biocidal products are mixtures of one or more active […]
The aim of the present project was to further develop a draft test guideline for an experimental method to study the transformation of veterinary pharmaceuticals and biocides in cattle and pig liquid manure, and to validate it in an international inter-laboratory comparison (ring test).
Veterinary medicinal products administered to animals are excreted with urine and faeces. For animals housed in stables, the resulting manure is collected and stored before being spread onto agricultural land. Disinfection products used to sanitize stables are also transferred into the manure. Therefore, the spreading of manure is an important pathway of introducing veterinary medicines, […]
In the authorisation process of biocidal products, the joint effects of the product components (active substances and relevant additives) shall be taken into account in the environmental risk assessment according to the relevant regulatory guidance. The concept of concentration addition (CA) is the proposed default model for this assessment. Open questions in this context are […]
ECT Oekotoxikologie GmbH was founded as a privately owned, independent enterprise in 1993, and joined the SynTech Research Group in November 2021.
In compliance with Good Laboratory Practice (GLP), we perform standardised ecotoxicological tests in the laboratory as well as at semi-field and field level.
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