The Innovative Medicines Initiative (IMI) project PREMIER aims to develop a centralised, user-friendly digital assessment system accessible for all relevant stakeholders. PREMIER will also explore options to incorporate environment considerations earlier in the drug development process to inform drug design and to reduce the need of animal testing. ECT is involved in this project as […]
The Innovative Medicines Initiative (IMI) project ‘Prioritisation and risk evaluation of medicines in the environment’ (PREMIER) aims to develop a centralised, user-friendly and transparent digital assessment system accessible for all relevant stakeholders such as regulatory agencies, pharmaceutical industry, water managers and environmental non-governmental organisations. Furthermore, PREMIER will explore the options to incorporate environment considerations earlier […]
The interaction of pollutants and pathogens may result in altered (often enhanced) effects of the chemical, the biotic stressor or both. While standardised detection methods for immunotoxic effects of chemicals exist with regard to human health, such test systems are lacking for invertebrate species and no guidance is available on how immunotoxic effects of a […]
Products used for plant protection or as biocides often contain more than one active substance together with numerous formulation additives. The environmental risk assessment for such commercial mixtures applies as default the concept of concentration addition. There is remaining regulatory concern, however, that underestimation of risks can occur if components in the mixture interact synergistically, […]
The aquatic environment is continually exposed to a complex mixture of chemicals, with effluents of wastewater treatment plants (WWTPs) as one key source. The aim of the present study was to investigate whether environmental risk assessments addressing individual substances are sufficiently protective for such mixtures. Based on a literature review of chemicals reported to occur […]
The SETAC Pellston Workshop ‘Simplifying environmental mixtures – an aquatic exposure-based approach via exposure scenarios’ addressed the need to improve mixture assessments by considering different exposure scenarios related to land use. Recently, a series of papers from this workshop was published in Environmental Toxicology and Chemistry, including the work ‘Use of prospective and retrospective risk assessment methods that simplify chemical mixtures associated with treated domestic wastewater discharges’, to which Anja Coors contributed.
The recently published work ‘Environmental risk assessment of biocidal products: identification of relevant components and reliability of a component-based mixture assessment’ contributes to the currently ongoing debate on how to perform a mixture assessment in the environmental risk assessment within the authorisation process of biocidal products. Biocidal products are mixtures of one or more active […]
The environmental fate of a compound is determined by transformation and distribution processes, which are strongly dependent on the specific environmental conditions. Biodegradability of chemicals in different environmental compartments is one of the major determinants of their environmental fate and therefore plays a crucial role in regulatory decision-making. Simulation studies according to OECD 308 (aquatic […]
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Premier
L. Schlüter-Vorberg
D. Leib
T. Junker