Tag Archive for: alternative to animal test

Hyalella azteca bioconcentration test (HYBIT)

ECHA recently announced that the Hyalella azteca bioconcentration test (HYBIT) can fulfil the standard information requirement under REACH for bioaccumulation, unless dietary exposure is required (read more). Thereby, the bioconcentration test (OECD TG 305) with fish will be replaced on a case-by-case basis with a test system that uses freshwater amphipods, i.e. non-vertebrates. A test […]

Development of a gene expression fish embryo test as an alternative for chronic fish tests: analysis of toxic effects using differential gene expression in the Danio rerio embryo test (Gene-DarT)

Acute and chronic fish tests are performed for the registration of chemicals, pesticides, biocides and pharmaceuticals. While the fish embryo test has been developed as an alternative to the acute fish test, so far no alternatives for chronic fish tests are available. Therefore, the fish embryo test with the zebrafish (Danio rerio) was extended by […]