Publication: Evidence for specific receptor-mediated toxicity of pharmaceuticals in aquatic organisms

The toxicity of 17 active pharmaceutical ingredients (APIs) was investigated using standardized acute and chronic tests with Daphnia magna and 2 algae species. Chronic toxicity was generally greater for Daphnia than for algae. Compilation of additional data resulted in 100 APIs for which the acute-to-chronic ratio (ACR) was determined for Daphnia. The frequency of high…

New publication on potential synergistic interaction between fungicides in toxicity tests with Raphidocelis subcapitata

Products used for plant protection or as biocides often contain more than one active substance together with numerous formulation additives. The environmental risk assessment for such commercial mixtures applies as default the concept of concentration addition. There is remaining regulatory concern, however, that underestimation of risks can occur if components in the mixture interact synergistically, […]

Review and enhancement of new risk assessment concepts under REACH

Within REACH, it is possible to waive standard tests that would be required for a chemical, if the available information from other tests and / or non-testing information (e.g. QSARs, grouping, read across) is considered sufficient to draw a reliable conclusion on the endpoint of concern. This concept is described as non-testing approach in the […]