News

Hyalella azteca bioconcentration test (HYBIT)

ECHA recently announced that the Hyalella azteca bioconcentration test (HYBIT) can fulfil the standard information requirement under REACH for bioaccumulation, unless dietary exposure is required (read more). Thereby, the bioconcentration test (OECD TG 305) with fish will be replaced on a case-by-case basis with a test system that uses freshwater amphipods, i.e. non-vertebrates. A test […]

New publication on TKTD modeling of sublethal endpoints for time‐variable toxicant exposure of Ceriodaphnia

Toxicokinetic-toxicodynamic (TKTD) modeling can integrate all available data from individual‐level bioassays into a single framework and enable refined risk assessments by extrapolating from laboratory results to time‐variable exposure scenarios. Dynamic energy budget (DEB) models coupled with TKTD modules (DEB-TKTD) are an approach to assess and predict sublethal effects of chemicals on individual organisms. However, thorough […]